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This Website is supported by funding from the Alfred P. Sloan Foundation.
Home > Areas of Focus > Countermeasure Development
Countermeasure Development
  

Analyses and reviews of the strategies and programs aimed at developing countermeasures critical for responding to major biological threats, and of the necessary contributions of government, academia, and biopharma essential to improving national and international response capacity.

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Alliance for Biosecurity
A collaboration among the Center for Biosecurity and 13 pharmaceutical and biotechnology companies who seek to engage government in public-private partnerships
 

Center Publications and Original Articles

Publications on Countermeasure Development

Articles written by Center staff relating to countermeasure developments.

  1. Drug and Vaccine Development for Infectious Diseases: The Value of Priority Review Vouchers

    Matheny J, Smith B, Courtney B, Mair M. Clinical Pharmacology & Therapeutics (2009); 85, 6, 571-572 doi:10.1038/clpt.2009.53
    Fri, 19 Jun 2009 18:33:40 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2009/2009-06-15-drug_vac_dev_inf_dis.html

  2. Developing Medical Countermeasures for Biodefense

    Smith BT, Mair M, Gronvall GK, Matheny J. Biosecurity and Bioterrorism. 2009;7(1).
    Mon, 30 Mar 2009 14:29:28 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2009/biomemo/2009-03-27-devel_med_cntrmeasures.html

  3. Strategic Priorities for U.S. Biosecurity

    O'Toole T, Inglesby TV. Biosecurity and Bioterrorism. 2009;7(1).
    Mon, 30 Mar 2009 14:26:47 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2009/biomemo/2009-03-27-strategic_priorities_biosecurity.html

  4. Cost/Success Projections for US Biodefense Countermeasure Development

    Matheny J, Mair M, Smith B. Nature Biotechnology. 2008;26(9):981-983.
    Thu, 11 Sep 2008 16:03:37 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2008/2008-09-01-costofbiodefense.html

  5. Biodefense Countermeasures: The Impact of Title IV of the US Pandemic and All-Hazards Preparedness Act

    Gronvall GK. Emerging Health Threats Journal. 2008;1:e3. doi: 10.3134/ehtj.08.003
    Fri, 07 Mar 2008 18:21:38 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2008/2008-03-07-biodefensecountermeasure.html

  6. Letter to Editor: The FDA Animal Efficacy Rule and Biodefense

    Gronvall G, Trent D, Borio L, Brey R, and Nagao L on behalf of the Alliance for Biosecurity. Nature Biotechnology 25, 1084 - 1087 (2007) doi:10.1038/nbt1007-1084
    Mon, 01 Oct 2007 19:19:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2007_orig-articles/2007-10-01-fdaanimalefficacyrulebiodefense.html

  7. Incentives for Biodefense Countermeasure Development

    Matheny J, Mair M, Mulcahy A, and Smith BT. Biosecurity and Bioterrorism. 2007;5(3).
    Sat, 15 Sep 2007 18:52:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2007_orig-articles/2007-09-15-incentivesbiodefensecountermeasure.html

  8. Flexible Defenses Roundtable Meeting: Promoting the Strategic Innovation of Medical Countermeasures

    Gronvall GK, Matheny J, Smith BT, Mair M, Chamberlain A, Deitch S, Borio L, Inglesby TV, and O'Toole T. Biosecurity and Bioterrorism. 2007;5(3).
    Sat, 15 Sep 2007 18:46:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2007_orig-articles/2007-09-15-flexibledefensesroundtablemeeting.html

  9. Biomedical Advanced Research and Development Authority (BARDA) Roundtable

    Gronvall GK, Smith BT, Matheny J, Mair M, Chamberlain A, Deitch S, Borio L, Inglesby TV, and O'Toole T. Biosecurity and Bioterrorism. 2007;5(2).
    Tue, 03 Jul 2007 20:00:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2007_orig-articles/2007-07-03-bardameetingreport.html

  10. Removing Barriers to Global Pandemic Influenza Vaccination

    Gronvall GK, Borio L. Biosecurity and Bioterrorism. 2006;4(2).
    Thu, 15 Jun 2006 14:48:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2006_orig-articles/2006-06-15-removingbarrierstoglobalpandemicfluvaccination.html


 
Center Commentary

commentary_countermeasure

Commentary by Center staff regarding countermeasure development.

  1. Center Recommends to White House $1.7 Billion in FY 2010 for BARDA (03-10-2009)

    In a letter to President Obama, the Center for Biosecurity Recommends $1.7 Billion in FY 2010 for BARDA's Advanced Research and Development Mission Appropriation.
    Tue, 10 Mar 2009 20:56:48 GMThttp://www.upmc-biosecurity.org/website/resources/commentary/2009-03-09-white_house_barda_fy10.html

  2. BARDA FY2010 Funding Recommendation - Letter to House (03-03-2009)

    The Center for Biosecurity recommends to the House of Representatives that BARDA receive $1.7 billion in FY 2010 for its advanced research and development mission.
    Wed, 04 Mar 2009 21:17:27 GMThttp://www.upmc-biosecurity.org/website/resources/commentary/2009-03-03-barda_fy10_house.html

  3. BARDA FY2010 Funding Recommendation - Letter to Senate (03-03-2009)

    The Center for Biosecurity recommends to the Senate that BARDA receive $1.7 billion in FY 2010 for its advanced research and development mission.
    Wed, 04 Mar 2009 21:15:38 GMThttp://www.upmc-biosecurity.org/website/resources/commentary/2009-03-03-barda_fy10_senate.html

  4. Letter of Support HR1 (02-11-2009)

    Center for Biosecurity urges Congress to support funding in the American Recovery and Reinvestment Act to help the nation prepare for and respond to chemical, biological, radiological, and nuclear (CBRN) weapons and pandemic flu.
    Wed, 11 Feb 2009 20:03:22 GMThttp://www.upmc-biosecurity.org/website/resources/commentary/2009-02-11_hr1_support_letter.html

  5. Comments on Designating Additions to the Current List of Tropical Diseases in the Food and Drug Administration Amendments Act (02-06-2009)

    Comments by Center for Biosecurity on Docket No. FDA-2008-N-0567: Designating Additions to the Current List of Tropical Diseases in the Food and Drug Administration Amendments Act
    Fri, 06 Feb 2009 21:26:00 GMThttp://www.upmc-biosecurity.org/website/resources/commentary/2009-02-06-add_to_list_tropical_diseases.html

  6. Letter of Support for Increase of BARDA Funding (09-04-2008)

    The Center for Biosecurity has submitted a letter to Congress in support of adding $905 million to BARDA funding through a White House amendment to the President's FY 2009 budget request.
    Thu, 04 Sep 2008 16:09:00 GMThttp://www.upmc-biosecurity.org/website/resources/commentary/2008-09-04-ltr_support_increase_barda.html

  7. Recommendations for BARDA funding for FY2009 (03-31-2008)

    Response to Senator Burr's request for the Center for Biosecurity's input regarding the levels of funding necessary for success in 2009 and beyond for the Biomedical Advanced Research and Development Authority (BARDA).
    Mon, 31 Mar 2008 16:24:00 GMThttp://www.upmc-biosecurity.org/website/resources/commentary/2008-03-31-barda_funding_fy09_burr.html

  8. BARDA FY09 Advanced Development Cost Estimates for Medical Countermeasures Against Biological Threats (01-31-2008)

    In FY'07 & '08, BARDA recieved $201 million for advanced development of biodefense countermeasures. Center for Biosecurity estimates that, for 90% probability of success, at least $817 million is needed in FY'09 and up to $3.4 billion annually.
    Thu, 31 Jan 2008 19:08:00 GMThttp://www.upmc-biosecurity.org/website/resources/commentary/2008-01-31-barda_fy09.html

  9. Ten Notable Publications of 2007 (01-08-2008)

    Center for Biosecurity's picks for 10 notable publications of 2007.
    Tue, 08 Jan 2008 23:15:00 GMThttp://www.upmc-biosecurity.org/website/resources/commentary/2008-01-08-notablepubs2007.html


 
Congressional Testimony and Briefings

Testimony on Countermeasure Development

Congressional testimony by Center staff regarding countermeasure development.

  1. Preparing for Bioterrorism: Project BioShield, BARDA and the Medical Countermeasure Enterprise (11-28-2007)

    A Capitol Hill briefing on the threat of bioterrorism, the status of developing new medicines and vaccines to counter biosecurity threats, and suggested four steps that the Congress can take to improve the current situation.
    Fri, 14 Dec 2007 19:30:15 GMThttp://www.upmc-biosecurity.org/website/resources/hearings/2007/2007-11-28-prepbioterrorism/index.html

  2. Six Years After Anthrax: Are We Better Prepared to Respond to Bioterrorism? (10-23-2007)

    Testimony of Tara O'Toole before the Senate Committee on Homeland Security and Governmental Affairs.
    Tue, 23 Oct 2007 16:48:00 GMThttp://www.upmc-biosecurity.org/website/resources/hearings/2007/20071023-sixyearsafteranthrax.html

  3. Hearing on "Project BioShield Reauthorization Issues" (04-06-2006)

    Testimony of Dr. Tara O'Toole before the Committee on Energy and Commerce, U.S. House of Representatives
    Thu, 06 Apr 2006 12:47:00 GMThttp://www.upmc-biosecurity.org/website/resources/hearings/2006/20060406bioshldreauth.html

  4. Department of Health and Human Services Budget Priorities for FY 2003 (02-28-2002)

    Testimony of Dr. Tara O'Toole before the Committee on the Budget, U.S. House of Representatives
    Thu, 28 Feb 2002 13:23:00 GMThttp://www.upmc-biosecurity.org/website/resources/hearings/2002/20020228FY2003budgetpriorities.html

  5. Hearing on FEMA's Role in Managing Bioterrorist Attacks and the Impact of Public Health Concerns on Bioterrorism Preparedness (07-23-2001)

    Testimony of Dr. Tara O'Toole before the Subcommittee on International Security, Proliferation and Federal Services, Committee on Government Affairs, U.S. Senate
    Mon, 23 Jul 2001 13:35:00 GMThttp://www.upmc-biosecurity.org/website/resources/hearings/2001/20010723femarole.html


 
Center Events and Scenarios

Atlantic Storm.
Washington, DC. January 14, 2005.

  
Multimedia

The Challenge of Bioterrorism, Present and Future: Keynote address delivered by Dr. Tara O’Toole in November 2008 at the Commissioned Training of Major Infectious Disease Emergencies and Bioterrorism Preparedness at Princess Margaret’s Hospital in Hong Kong. Watch the video | View the slides | View other lectures from this conference

Atlantic Storm: Lecture delivered by Dr. Thomas Inglesby in November 2008 at the Commissioned Training of Major Infectious Disease Emergencies and Bioterrorism Preparedness at Princess Margaret’s Hospital in Hong Kong. Watch the video | View the slides | View other lectures from this conference

Atlantic Storm Interactive

Video of talk given by Dr. Thomas Inglesby, at the HHS Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) Stakeholders Workshop 2008 and BARDA Industry Day on September 25, 2008. Dr. Inglesby was a member of the panel addressing Strategies and Suggestions for Developing and Sustaining a Biodefense Industry. View the video | View the slides

Slide lecture: "Polio Eradication: A Reconsideration of Strategy," a lecture delivered by Dr. D.A. Henderson for the John Snow Society (the 2007 Annual Pumphandle Lecture). Listen to the lecture | View the slides

Video of talk given by Tara O’Toole, MD, MPH, at the HHS Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) Stakeholders Workshop on July 31, 2007. Dr. O’Toole was a member of the Academia/Science Panel addressing CBRN Medical Countermeasure Preparedness Efforts - Stakeholder Response.

Slide set: “Biosecurity Now and for the Long Run,” from the Thomas Glasser lecture delivered by Tom Inglesby, MD, on April 26, 2007, for the Overlook Hospital Foundation. Note: Statistics and facts included in the slides were current as of April 2007 and have not been updated.

  
U.S. Government Documents

U.S. government documents and reports related to countermeasure development

U.S. government documents – all topic areas

Biosecurity-related federal legislation

  
See Also

Clinicians' Biosecurity Network Report Archive: Countermeasure Development

Testimony Submitted to the House of Representatives Labor, Health and Human Services, and Education Appropriations Subcommittee Regarding FY 2010 Funding for Barda Advanced Research and Development, David P. Wright, Co-Chair Alliance for Biosecurity, March 18, 2009

FDA Priority Review Voucher Program – DRAFT Guidance for Industry

DARPA Defense Sciences Office – Biological Warfare Defense

CDC Division of Strategic National Stockpile

HHS MedicalCountermeasures.gov

Casting a Wider Net for Countermeasure R&D Funding Decisions. Klotz L. Biosecurity and Bioterrorism. 2007;5(4).

Security is More than Public Health: Commentary on ‘Casting a Wider Net for Countermeasure R&D Funding Decisions’. Epstein GL. Biosecurity and Bioterrorism. 2007;5(4).

Brief on the Global Biotechnology and Pharmaceutical Industries. Jason Matheny, 2007.

HHS Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA)

National Institutes of Allergy and Infectious Diseases (NIAID) Biodefense Research: National Institutes of Health (NIH)/NIAID

The Critical Path to New Medical Products Initiative: U.S. Food and Drug Administration (FDA)

Official Website of the of the Office of the Special Assistant for Chemical and Biological Defense and Chemical Demilitarization Programs: U.S. Department of Defense (DoD)

Advancing Science. Serving Society (AAAS) R&D Budget and Policy Program: Annual analysis of U.S. federal spending on research and development

American Society for Microbiology (ASM) Biodefense Conference: Annual ASM Biodefense and Emerging Diseases Research Meeting

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